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At a Glance
Two phases that effectively combat canine Cushing's disease
Easy to administer in chewable tablet form


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At a Glance
Two phases that effectively combat canine Cushing's disease
Easy to administer in chewable tablet form

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Lysodren is a treatment option for dogs that have been diagnosed with canine Cushing's disease. This medication has two phases: a "loading" phase and a "maintenance" phase. The combination of the medication's two phases allows for better care of your dog's disease so he or she can be feeling like normal in no time.

Lysodren is a perfect treatment option as it is kind to your wallet. In addition, Lysodren is incredibly easy to administer to your dog. This treatment option is not a shot or a pill that you have to force your dog to swallow by hiding it in its food. There is no need to tempt your dog to take its medication in numerous unhealthy treats as this medication comes in a convenient chewable tablet.

Do not use the drug on animals that are hypersensitive to mitotane, which is the active ingredient present in the medicine. The medication should not be tried in pregnant as well as nursing animals. Mitotane has a tendency to interact when used with insulin or spironolactone and in certain other combinations of medicines. It would be wise to inform the veterinarian of the medication that the pet is currently receiving. Personal protection is also important in dealing with the medication, as mitotane is cytotoxic to humans. If in case the drug comes in contact with the skin it has to be washed off immediately. Instances of medication overdose could be fatal if not attended to.

The medication has side effects in animals that might lead to Addison's disease or its symptoms such as decreased appetite, vomiting and diarrhea, lethargy, weakness etc. Observe the symptoms and in the event of severe reactions to the medicine, supplement with glucocorticoids like prednisone.

Lysodren is the Generic Alternative to Mitotane.

  • Thyroid Pharmacy
  • Bristol Meyers Squibb Manufacturer
  • Oral Application
  • Dog Pet Type

What is Lysodren used for?

Lysodren, also known as mitotane, is a medication used in veterinary medicine for the treatment of hyperadrenocorticism, commonly known as Cushing's disease, in dogs. NIH notes that Cushing's disease is a hormonal disorder characterized by an overproduction of cortisol, a steroid hormone, by the adrenal glands. This condition can result in various symptoms such as increased thirst and urination, weight gain, hair loss, and muscle weakness. According to Molly Price, a small animal medicine specialist and DVM graduate of Texas A&M College of Veterinary Medicine, Lysodren works by destroying the outer layer of the adrenal glands, where cortisol is produced. Lysodren helps reduce the symptoms of Cushing's disease by lowering cortisol production. However, it is crucial to remember that Lysodren is a strong drug with potential adverse effects that must be carefully monitored by a veterinarian. Regular blood tests are performed to check cortisol levels, and dose modifications may be made to successfully treat the disease while reducing side effects. Lysodren is not a general-purpose medication and should only be used under veterinary supervision for dogs diagnosed with this hormonal disorder.

What is the new drug for Cushingโ€™s disease?

Trilostane (Vetoryl) is a medication often used to treat Cushing's disease (hyperadrenocorticism) in dogs. Trilostane acts by suppressing cortisol production, which is high in dogs with Cushing's disease. It is frequently given to treat the symptoms of this illness. As noted by MSD Veterinary Manuals, trilostane functions as an inhibitor of 3-beta-hydroxysteroid dehydrogenase, an enzyme crucial for cortisol synthesis. By impeding cortisol production, trilostane effectively alleviates the symptoms associated with Cushing's disease. This includes excessive thirst, increased urination, and skin issues. The treatment plans for Cushing's disease in dogs may involve a combination of medications, dietary management, and regular monitoring of your pet's behavior. This helps optimize the overall well-being of the affected animals. Some combination medicines that are used in the management of Cushing's disease in dogs include Anipryl and Ketoconazole. Aldosterone receptor antagonists, such as Spironolactone, may also be part of combination therapies for managing Cushing's disease in dogs.

What is the treatment for high cortisol?

The treatment for high cortisol levels in dogs typically involves addressing the underlying cause and managing symptoms. Elevated cortisol, often associated with conditions such as Cushing's disease, may require a multifaceted approach. According to Pet Honesty, the most common cause of increased cortisol levels in dogs is tumor formation in either the pituitary or adrenal gland. A gland tumor in either of these places stimulates the adrenal glands, causing an increase in cortisol production. In some cases, veterinary professionals may recommend surgery to remove adrenal tumors or prescribe medications like trilostane or mitotane to regulate cortisol production. Based on the assessment of Colorado-based veterinarian Jo Myers, dogs that undergo surgery while being sick face a 50% risk of not surviving the procedure. These drugs work by inhibiting the overactive adrenal glands, helping to restore hormonal balance. Additionally, dietary modifications, such as low-fat and low-sodium diets, may be recommended to manage weight gain and other symptoms associated with high cortisol. Regular monitoring through blood tests and imaging studies is crucial to assess the effectiveness of the treatment and make necessary adjustments. It's important for pet owners to closely follow the veterinarian's recommendations and attend regular check-ups to ensure the dog's well-being. Alongside medical interventions, supportive care, such as providing a comfortable and stress-free environment, plays a key role in managing cortisol levels. In some cases, complementary therapies like acupuncture or herbal supplements may be considered, but their efficacy should be discussed with the veterinarian.

What is the best food to lower cortisol?

In dogs, managing cortisol levels through diet involves selecting nutrient-rich foods that support overall health and well-being. A balanced diet with adequate protein, moderate fat, and complex carbohydrates is essential. Opting for high-quality, whole-food ingredients can contribute to a stable blood sugar level, which, in turn, helps regulate cortisol production. Foods rich in omega-3 fatty acids, such as fish oil, may have anti-inflammatory properties and potentially assist in cortisol modulation. Incorporating fruits and vegetables, especially those high in antioxidants, can be beneficial. Antioxidants help combat oxidative stress and may indirectly influence cortisol levels. Examples include blueberries, spinach, and carrots. Additionally, ensuring proper hydration is crucial for overall health, and water intake can indirectly affect cortisol balance.

What are the three symptoms of Cushingโ€™s?

Cushing's disease, or hyperadrenocorticism, in dogs, is characterized by excessive production of cortisol, a steroid hormone. Three common symptoms associated with Cushing's disease include polyuria, polydipsia, and polyphagia. Polyuria refers to increased urination frequency and volume. Dogs with Cushing's often experience excessive water intake, leading to the need for more frequent urination. Polydipsia, or increased thirst, is closely linked to polyuria, as the body attempts to compensate for fluid loss through elevated water consumption. These symptoms may result in more frequent trips outdoors for bathroom breaks and increased water bowl refills. Polyphagia, or excessive appetite, is another hallmark of Cushing's disease. Affected dogs may exhibit a heightened interest in food, constantly seeking additional meals or treats. Despite increased food intake, they may not gain weight proportionally, and some may even experience muscle wasting. Other common signs of Cushing's in dogs include a pot-bellied appearance, thinning or fragile skin, hair loss, and increased susceptibility to infections. It's important to note that these symptoms can vary, and not all dogs with Cushing's will display the same combination or severity of signs.


In treating Cushing's Disease, lysodren may erode the adrenal cortex so far as to create a cortisone defiency, either temporarily or irreparably. The latter case is referred to as Addisonโ€™s disease. Symptoms include loss of appetite, vomiting, diarrhea , weakness and drowsiness. Contact a veterinarian immediately if symptoms are observed.

This medication should not be used in animals that are allergic to it. Do not use in pregnant or nursing animals. Use with caution in animals with kidney or liver disease. Use caution when used with insulin or spironolactone.

Lysodren is a cytotoxic drug used in veterinary medicine to treat Cushingโ€™s disease and the related symptoms in dogs. The medication is strong enough to deactivate the cells in a particular area of the adrenal gland, thus reducing the functionality of that particular part of the gland. Therapeutic effects that the medicine displays are attached to Mitotane, the active component present, which works by holding back the adrenal gland functions. This is done by limiting the amount of cortisol being produced in the body. Lysodren is a prescription drug and comes in scores tablets.ย 

Consult your veterinarian for dosing and accompanying treatment, and for caution regarding drug interaction. Be prepared to monitor your pet regularly with blood tests.

Lysodren follows a treatment regimen of a "loading phase" followed by a "maintenance phase" in order to help you manage your pet's illness.

Do not handle Lysodren with your bare hands, particularly if you are pregnant or trying to get pregnant.

Store at room temperature and protect from light

Lysodren is manufactured by Bristol Meyers Squibb

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

Related Articles

Cushing's Disease in Cats: An Overview

What is the Feline Cushingโ€™s Disease and How to Treat It

Read More

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Great product! Fast shipping! Great experience overall!

Ronda H recommends this item.
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Amazing product

Ronda recommends this item.
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Best pet pharmacy on the internet!

I won't buy my pet meds any place else. The time and caring the associates give you is amazing. I have the utmost confidence in ordering from PetCareRX. Shipping is very fast, and their methods of communication are spot on! I am so glad I found the best place for all my animals prescription needs!

kathie recommends this item.
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Works wonders.

I bought this product for my dog when she was diagnosed about 6 years ago. When I first bought this I went to a regular pharmacy and was charged $500 was this medication because they told me not many people were on it and I had to purchase the whole bottle of 100 tablets. Now I guess it's more out there and cheaper to buy. Great deal....

Mare recommends this item.
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Thank you

It was VERY helpful to read how well other dogs have done on this med! My 13 yo dog was recently diagnosed with Cushings Disease and will have to start this med as well. Thanks for the hope!

poodle_runner recommends this item.
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Lusodren works

My dog has recovered from cancer twice and she now has has Cushings disease for 3 years. She gets 1/2 of a 500mg pill 2x per week and weighs 35 lbs. She needs a pepcid ac pill when she takes the lysodren and is doing fine at 13 years old!!!

Dave recommends this item.
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Lysodren works!!

My dog was diagnosed with Cushings Disease 4 years ago. Casey is on Lysodren, carefully monitored by our Veterinarian, and is doing beautifully! She has had no side effects and is a happy, healthy 13 year old Lab.

Dogs_and_cats_owner_for_many_years recommends this item.
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It's a miracle

Sadie was diagnosed with Cushings. My vet advised against starting treatment (Lysodren) until she deteriorated greatly saying the treatment could be worse than the disease. However, she lacked energy, drank all the time,therefore had accidents, was starving,etc. . She was losing her hair (her tail was almost bald & she's a poodle!)Once she went on Lysodren, she's was like a new dog. Active, her appetite & thirst are under control. Even more amazing is that she grew back a lush thick coat which is dark red like it was when she was a puppy! It improved her quality of life tremendously! *This is a prescription item.

Marilyn recommends this item.
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