Hover image to zoom Tap and hold image to zoom
Refills on File
Your pet {{refill.petName}} has {{refill.refillsRemaining}} refill{{refill.refillsRemaining>1?'s':''}} for ‘{{refill.options}}’ which will expire on {{refill.expiresOn}}.
{{refill.petName}}'s refills for this have expired on {{refill.expiresOn}}
At a Glance
Two phases that effectively combat canine Cushing's disease
Easy to administer in chewable tablet form


List Price:
{{list_price * quantity | currency}}
List Price:
{{list_price * quantity | currency}} {{(list_price + 0.01) * quantity | currency}}
List Price:
{{list_price * quantity | currency}}
List Price:
See price in cart
PetPlus Price:
{{petplus_price * quantity |currency}}
PetPlus Price:
See price in cart
Sale Price:
{{sale_price * quantity|currency}}w/code {{siteCode}}
Your Price:
{{map_price + 0.01 | currency}} See price in cart w/code {{siteCode}}
{{petplus_savings_amount * quantity|currency}} ({{petplus_savings_percent}}%)
{{coupon_savings_amount * quantity|currency}} ({{coupon_savings_percent}}%)
Join PetPlus today and get this for {{intro_price_total|currency}}
Join PetPlus today and {{use_strict_map_rules?"see price in cart":"get this for a special price"}}

inlowout of stock
Get notified as soon as this becomes available
Thank you.
We will email {{notifyEmail}} when this is back in stock.
Recommended Alternatives:
Limit ( {{ selected_sku_data.cartLimit }} ) per customer. Orders for more than this may not be fulfilled.
Shipping is always free with PetPlus | Arrives in 1-3 days on average
Free shipping over $48* | Arrives in 1-3 days on average
Select Autoship options at checkout
At a Glance
Two phases that effectively combat canine Cushing's disease
Easy to administer in chewable tablet form

Lysodren is a treatment option for dogs that have been diagnosed with canine Cushing's disease. This medication has two phases: a "loading" phase and a "maintenance" phase. The combination of the medication's two phases allows for better care of your dog's disease so he or she can be feeling like normal in no time.

Lysodren is a perfect treatment option as it is kind to your wallet. In addition, Lysodren is incredibly easy to administer to your dog. This treatment option is not a shot or a pill that you have to force your dog to swallow by hiding it in its food. There is no need to tempt your dog to take its medication in numerous unhealthy treats as this medication comes in a convenient chewable tablet.

Do not use the drug on animals that are hypersensitive to mitotane, which is the active ingredient present in the medicine. The medication should not be tried in pregnant as well as nursing animals. Mitotane has a tendency to interact when used with insulin or spironolactone and in certain other combinations of medicines. It would be wise to inform the veterinarian of the medication that the pet is currently receiving. Personal protection is also important in dealing with the medication, as mitotane is cytotoxic to humans. If in case the drug comes in contact with the skin it has to be washed off immediately. Instances of medication overdose could be fatal if not attended to.

The medication has side effects in animals that might lead to Addison's disease or its symptoms such as decreased appetite, vomiting and diarrhea, lethargy, weakness etc. Observe the symptoms and in the event of severe reactions to the medicine, supplement with glucocorticoids like prednisone.

Lysodren is the Generic Alternative to Mitotane.

  • Thyroid Pharmacy
  • Bristol Meyers Squibb Manufacturer
  • Oral Application
  • Dog Pet Type


In treating Cushing's Disease, lysodren may erode the adrenal cortex so far as to create a cortisone defiency, either temporarily or irreparably. The latter case is referred to as Addisonโ€™s disease. Symptoms include loss of appetite, vomiting, diarrhea , weakness and drowsiness. Contact a veterinarian immediately if symptoms are observed.

This medication should not be used in animals that are allergic to it. Do not use in pregnant or nursing animals. Use with caution in animals with kidney or liver disease. Use caution when used with insulin or spironolactone.

Lysodren is a cytotoxic drug used in veterinary medicine to treat Cushingโ€™s disease and the related symptoms in dogs. The medication is strong enough to deactivate the cells in a particular area of the adrenal gland, thus reducing the functionality of that particular part of the gland. Therapeutic effects that the medicine displays are attached to Mitotane, the active component present, which works by holding back the adrenal gland functions. This is done by limiting the amount of cortisol being produced in the body. Lysodren is a prescription drug and comes in scores tablets.ย 

Consult your veterinarian for dosing and accompanying treatment, and for caution regarding drug interaction. Be prepared to monitor your pet regularly with blood tests.

Lysodren follows a treatment regimen of a "loading phase" followed by a "maintenance phase" in order to help you manage your pet's illness.

Do not handle Lysodren with your bare hands, particularly if you are pregnant or trying to get pregnant.

Store at room temperature and protect from light

Lysodren is manufactured by Bristol Meyers Squibb

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

Customers Also Bought These Items

Related Articles

7 Warnings Signs of Cushing's Disease in Dogs

Catching Cushing's Disease Early

Read More
Cushing's Disease in Cats: An Overview

What is the Feline Cushingโ€™s Disease and How to Treat It

Read More

Customer Reviews

Overall Rating

5 / 5
* = required

New Product Review

Uploaded Image 1
Uploaded Image 2
Uploaded Image 3
  • {{error}}
Showing 1 - {{visible_reviews.length}} of 8

This product has no reviews yet. Write a review.

Page 1 of 1 1