Diphenhydramine Rx (Generic Benadryl) 25mg
Diphenhydramine Rx (Generic Benadryl) 25mg
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At a Glance
Treats allergy symptoms and itching related to insect bites or stings
Sedative/tranquilizer to treat motion sickness or travel anxiety
Safe for all ages and weights of dogs or cats

Diphenhydramine Rx (Generic Benadryl) 25mg

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At a Glance
Treats allergy symptoms and itching related to insect bites or stings
Sedative/tranquilizer to treat motion sickness or travel anxiety
Safe for all ages and weights of dogs or cats

Diphenhydramine is an antihistamine, also known as the generic form of Benedryl. It is used to treat allergies, insect stings/bites, motion sickness and travel anxiety. The medication is safe for all ages and weights of dogs or cats. It should not be used by dogs or cats that are pregnant or nursing.

Dosage is .5-2mg per pound of your pet; be sure to administer the proper dosage. See directions below and your package instructions for details. Always follow your veterinarian's prescribed dosage if it differs from the standard dosage recommendations.

Diphenhydramine is the Generic Alternative to Benadryl and/or Apoquel.

Diphenhydramine HCL should be used with caution in pets suffering from angle-closure glaucoma, prostatic hypertrophy, bladder neck or pyloroduodenal obstruction, COPD, hyperthyroidism, cardiovascular disease, or hypertension. Should only be used in pregnant patients when the benefits outweigh the risks. Taking diphenhydramine with CNS depressants might cause excessive depression of the central nervous system. MAOI inhibitors might intensify the anticholinergic effects of diphenhydramine. Diphenhydramine might overly enhance the effects of epinephrine, and counteract the anticoagulant effects of heparin or warfarin. Possible side effects of diphenhydramine HCL are CNS depression, dry mouth, urine retention, vomiting, diarrhea, and loss of appetite. The sedative effects of diphenhydramine might lessen over repeated uses. In some cats, a paradoxical CNS excitation might occur.

  • Behavior & Anxiety Management Pharmacy
  • Allergy Relief Pharmacy
  • Care Wellness Philosophy
  • Pregnant Reproductive
  • Anxiety Behavior Issues
  • Ivermectin Sensitivity Allergies
  • Non-Prescription Pharmacy Type
  • Rope Material
  • Oral Application
  • Cat Pet Type
  • Dog Pet Type

Can I Give My Dog Diphenhydramine 25 MG?

General Benadryl, also known by its generic name, Diphenhydramine, is one of the few over-the-counter drugs that veterinarians commonly advise pet parents to administer at home. The medication is often used to ease the dog's anxiety or treat mild allergic reactions caused by one reason or another. Typically, Benadryl is well tolerated by most dogs and has a wide safety margin. According to veterinarians, the general rule of thumb for administering Benadryl is 1mg per pound of your dog's body weight. Therefore, give your dog Diphenhydramine 25mg only if your dog weighs 25 pounds. Smaller dogs will require you to cut or divide these 25 mg dosages. Moreover, the recommended dosage is 1mg per pound of bodyweight twice or thrice a day, and you should follow the same.

What Is Prescription Strength Diphenhydramine?

Dogs are hyper-active and pretty curious by nature, and therefore they might find themselves in sticky situations more often than not. From getting stung by a bee to coming into contact with poison ivy or seasonal allergies, some common instances will lead to your dog suffering from allergic reactions. Your dog doesn't have to suffer through. With a vet's consultation, you can give Diphenhydramine to your d to alleviate the worsening of symptoms. Diphenhydramine or Benadryl is an antihistamine that relieves the symptoms of allergies in both humans and dogs. However, naturally, the dosage is different for humans and dogs. Dogs metabolize Diphenhydramine differently and therefore should not be given the human dosage. The correct dosage of Diphenhydramine for dogs depends entirely on the size and weight of the dog. Simply speaking, smaller dogs will need a much smaller dose than a giant dog to receive the same results. The Merck Veterinary Manual states that a safe dose is 2-4 milligrams per kilogram of the body weight.

Is Diphenhydramine Safe for Pets?

Yes, Diphenhydramine or general Benadryl is entirely safe to give to your pet. This particular antihistamine helps in relieving the symptoms of allergies in both humans and animals. Apart from allergic reactions, the medication is also safe to treat the symptoms of motion sickness caused by long-distance transportation in dogs. For most dogs, the vet-suggested dosage of Benadryl is entirely safe.

How Much Diphenhydramine Can I Give My Dog?

Diphenhydramine is a human medication that also works very well to treat allergic, anxiety, and motion sickness in animals. However, the size of dosage varies hugely for animals as compared to humans. The commonly suggested dosage for dogs and other animals is 2-4 milligrams of medication per kilogram of their body weight. Or simply put, 1mg per pound of the body weight. This means, if your dog weighs 10 pounds, the recommended dosage will be 10mg twice or thrice a day. The frequency of administration will vary depending on the severity of the symptoms in your dog.

Is It Safe to Take Diphenhydramine Every Night?

It's safe to administer Diphenhydramine to your dog every 8-12 hours, which is twice or thrice a day. Your Veterinarian will be able to guide you with the correct dosage for your dog depending on its weight and breed. However, as is the case with every medication, the effectiveness of Diphenhydramine goes down with the frequency of usage. Therefore, use only in case your dog has allergic reactions and until the reaction persists.

Will Diphenhydramine Sedate My Dog?

To sedate your dog or put him to sleep, Benadryl or Diphenhydramine is not the best option. This is particularly true if your dog is very active or anxious. Additionally, in some dogs, the medication might cause hyperactivity instead of inducing lethargy. On the other hand, the drug does have some efficacy in preventing motion sickness in dogs and acts as a mild sedative. However, the effect is not the same for all dogs.

Is Diphenhydramine Fatal to Dogs?

Diphenhydramine is a first-generation antihistamine, which is commonly sold under the brand name Benadryl. Benadryl with just Diphenhydramine is entirely safe for both humans and dogs. However, look for additional ingredients such as phenylephrine, which is toxic to dogs. While the medication is largely safe for all dogs, overdosing a high amount of the drug might cause some side effects. These include depression, drooling, excitability, lack of appetite, rapid breathing, rapid heart rate, aggression, fever, muscle tremors, and more. In case your dog is showing any of the symptoms listed above, it would be wise to consult a veterinarian right away to avoid any mishap.


Diphenhydramine HcL is an ethanolamine derivative H1 receptor antihistamine, with secondary sedative, anticholinergic, antitussive, and antiemetic effects. In other words, this drug blocks the part of the brain that responds to allergens (histamine), relaxes them, keeps them from coughing, and prevents nausea. Most offten used in pets that suffer from seasonal allergies, this medication is helpful when dealing with rashes, like pruritus or insect bites, or when dealing with motion sickness. Available in multiple strengths (prescription and OTC) and as a tablet or an injectable, there are a number of different ways to optimize the way your pet receives their treatment depending on their condition.ย 

Common side effects are drowsiness and dry mouth. Your pet may also develop urinary retention. Other side effects that are less common include diarrhea, vomiting and lack of appetite. If any symptoms appear to distress your animal, contact your veterinarian. Always tell your veterinarian all the medicines your pet is on before adding new medications.

Do not use if cat or dog is pregnant or nursing. Do not administer to pets suffering from glaucoma, high blood pressure, urinary obstruction, and prostate disease. Use with caution when given with other CNS (central nervous system)-depressant drugs such as tranquilizers or barbiturates.

Use caution when used in conjunction with CNS depressants, heparin, warfarin, and epinephrine.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Use as directed by your veterinarian. The typical dosage is .5-2mg per pound. Administer the pill orally. Do not mix in with food.

For dogs, anywhere between 1 - 4 mg/kg orally or IM every 8 hours
For cats, anywhere between 0.5 - 4 mg/kg orally or IM every 8 hoursย 

Store at room temperature, away from excess heat, light and moisture.

Option UPC/SKU
25mg / 100 capsules 309045306604

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