How is Dog Mammary Tumor Therapy advancing?

How is Dog Mammary Tumor Therapy advancing?

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Mammary tumors are commonly seen in middle-aged or older female dogs.ย  The risk factors in such cases are due to increased age exposure to ovarian and growth hormones, ovariectomy after 2.5 years of age andย obesityย at a young age.

Just about most of these tumors are malignant. A local recurrence and distant spread is, however, possible following their removal through surgical processes. Prognosis is affected by the tumor size, type grade and clinical stage wherein there might occur a spread of disease throughout the body during the time of diagnosis. While these tumors are rarely fatal, they remain a major health concern for owners of female dogs.

Researchers at the Ohio State University are exploring the use of optical coherence tomography (OCT) in order to help doctors reach important and required margins during surgical removal of mammary tumors and soft tissue sarcomas in female dogs.

Optical Coherence Tomography (OCT)

  • Have functions similar to an ultrasound. 
  • Uses light reflected to dig deep instead of using sound waves as used in ultrasound
  • The light reflects from various tissue surfaces and provides a high-resolution(with regards to the tumor)
  •  A cross-sectional image of the tissue structure in the present place and time can be seen
  • Helps distinguish between soft tissue sarcoma, muscle tissue, and fatty tissue

Once the mammary tumor is caught, the use of OCT could provide an accurate and intra-operative method to determine surgical margins.

Thankfully due to AKC CHF Grant 2204-T: employing advanced imaging techniques, it has become comparatively easier to calculate tumor signs for mammary cancer in dogs and Soft Tissue Sarcoma.

Researchers have already taken the first step toward reaching their accomplishment. 

Veterinary medicine is on the path to achieve high grounds marking treatment targets for mammary tumors in dogs. A research at the University of Pennsylvania has found properties of collagen in the tumor microenvironment for dogs which identity with patient survival time.

CHF Grant 2489: Tumor-permissive Collagen Signatures in Mammary Gland Tumors for dogs:

Progression in the form of Prognostic Markers, as well as Targeted Therapies for the improved outcome, should help researchers study the naturally occurring mammary tumors in dogs adopted or placed in permanent foster care, taking up a program called โ€˜Penn Vet Shelter Canine Mammary Tumor Program.' This is known to provide a full lifelong mammary tumor care for dogs enrolled here and also gives data related to the research a measure through the clinical outcome.

Herein, research also shall explore added collagen traits that foretell outcomes and scrutinize their affect tumor behavior. They hope to develop modes that should avoid the formation of  tumor-friendly microenvironments in the mammary glands of dogs.

A well-known treatment for mammary tumors in dogs would be a surgical removal is. However, this situation is age sensitive to a dog. If the dog is of much age, it is at a much higher risk due to after surgery conditions for a dog as immense care is to be given to the dog in order for it to heal and regain its strength.

CHF-funded studies are capable of providing a tool which is known to allow doctors to completely remove the tumor tissue in one go.

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