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2x PetCareRx Points
Requires Prescription
At a Glance
Trifexis kills fleas, prevents heartworm, and treats and controls intestinal parasites
Trifexis is a once monthly beef flavored chewable tablet
No isolation from other pets necessary when using Trifexis


An alternative to Trifexis is Sentinel

Trifexis is a powerful and effective means of preventing heartworm disease, as well as protect against fleas and a number of other worms and parasites. [+]

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This product requires a prescription.
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Customer Reviews

Rated 4.4 out of 5 by 108 reviewers.
Rated 5 out of 5 by Trifexis I like that it is once a month. I wish it worked for ticks too. Only drawback is it gives my dog a rash on his belly but nothing that isn't helped by daily Benadryl. October 5, 2015
Rated 4 out of 5 by Horrible smell, bad taste My dog has been using Trifexis since he was a puppy, and I have never had any problems with him taking the pills each month. But, since he has moved up to over 60 pounds, I have to fight with him to get the pill in him. I've tried crushing it up and hiding it in food, hiding a whole pill in a treat, anything you can think of. I cannot even open the package in front of him without him running off and hiding. The larger pill smells horrible, and I can't help but wonder if that is why? My previous dog was on the larger dose, and I had the same problem with him. Does anybody else have any problem trying to get their dog to take the large pill? It's almost becoming too traumatic for both of us to deal with this every month. October 3, 2015
Rated 5 out of 5 by A bit pricy Works better than any other flea control. No fleas ever September 14, 2015
Rated 5 out of 5 by Effective No problems with Heart worms or fleas. Requires camouflage for my 2 Malinois to swallow without force. Would use a generic brand if cost was reduced. September 11, 2015
Rated 4 out of 5 by a good fit have a dog that can not handle the topical products, but will eat anything so this is great for her. it does have a notifiable odor to it. The worse it smells the better for her. Add it to her food, cannot get ant easier. September 11, 2015
Rated 5 out of 5 by Trifexis is effective and easy to administer Have used this product with both my dogs and never had an issue with fleas while simultaneously treating them with heartworm prevention. The website saves a little money and is easy to use. Your vet may not be efficient allowing for the prescription. August 25, 2015
Rated 5 out of 5 by Good product for great price I've been paying way too much at my vets office for this product. This is effective way to prevent ticks, fleas and worms. Highly recommend. August 23, 2015
Rated 4 out of 5 by Product is simple to use. I won't go back to the mess of applications (of sorts) again. I Hide it in some peanut butter and once in a while I can get them to just take the pill. August 3, 2015
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Customer Q&A

Elanco Animal Health Flea & Tick Trifexis Trifexis is a powerful and effective means of preventing heartworm disease, as well as protect against fleas and a number of other worms and parasites. prescription 122.49 Condition: new In stock! Order now!
Trifexis 4 out of 5 0 based on 108 ratings.