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2x PetCareRx Points
Requires Prescription
At a Glance
Trifexis kills fleas, prevents heartworm, and treats and controls intestinal parasites
Trifexis is a once monthly beef flavored chewable tablet
No isolation from other pets necessary when using Trifexis


An alternative to Trifexis is Sentinel

Trifexis is a powerful and effective means of preventing heartworm disease, as well as protect against fleas and a number of other worms and parasites. [+]

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This product requires a prescription.
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Customer Reviews

Rated 4.4 out of 5 by 106 reviewers.
Rated 5 out of 5 by A bit pricy Works better than any other flea control. No fleas ever September 14, 2015
Rated 5 out of 5 by Effective No problems with Heart worms or fleas. Requires camouflage for my 2 Malinois to swallow without force. Would use a generic brand if cost was reduced. September 11, 2015
Rated 4 out of 5 by a good fit have a dog that can not handle the topical products, but will eat anything so this is great for her. it does have a notifiable odor to it. The worse it smells the better for her. Add it to her food, cannot get ant easier. September 11, 2015
Rated 5 out of 5 by Trifexis is effective and easy to administer Have used this product with both my dogs and never had an issue with fleas while simultaneously treating them with heartworm prevention. The website saves a little money and is easy to use. Your vet may not be efficient allowing for the prescription. August 25, 2015
Rated 5 out of 5 by Good product for great price I've been paying way too much at my vets office for this product. This is effective way to prevent ticks, fleas and worms. Highly recommend. August 23, 2015
Rated 4 out of 5 by Product is simple to use. I won't go back to the mess of applications (of sorts) again. I Hide it in some peanut butter and once in a while I can get them to just take the pill. August 3, 2015
Rated 5 out of 5 by Trifexis makes my dog nausaus for a couple of days after she takes it. PLEASE, do not deliver her meds in a hard box anymore because I could not get the box out of the US Postal Service receptical and had to wait 3 days to get it.....not good in this heat. PLEASE do not deliver it again in a hard box. July 22, 2015
Rated 4 out of 5 by Good product, fair price, but slow. I ordered a medication and immediately mailed in the vet's prescription. Waited about 2 weeks to receive the meds. The price (especially with the PetPlus discount) was worth the wait. All in all, with advance planning, PetCare Rx is preferable to the steep mark-up my vet would have charged. I appreciated the notifications via e-mail and phone on the progress of my order. July 21, 2015
  • 2015-10-02T05:33:00.944-05:00
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Customer Q&A

Elanco Animal Health Flea & Tick Trifexis Trifexis is a powerful and effective means of preventing heartworm disease, as well as protect against fleas and a number of other worms and parasites. prescription 122.49 Condition: new In stock! Order now!
Trifexis 4 out of 5 0 based on 106 ratings.