Leukeran
Generic Name
Chlorambucil
Indications/Uses
Leukeran, a derivative of the nitrogen mustard chemical group is a veterinary medication used in treating leukemia as well as Hodgkin’s disease in dogs and cats. Recognized as the alkylating agent, the medication is also effective in the management of the cancer affecting lymphatic system and tumors. The drug is also used in treating certain other immune-mediated conditions in animals. Chlorambucil, the active ingredient present in the medication is an antineoplastic and immunosuppressant, which acts by connecting DNA strands to modify protein formation. The medication also augments the production of lymphocytes, thus proving effective in the management of diseases that affects the immune system of animals, especially in cats. Leukeran is available only by prescription and comes in 2mg sugar coated tablets.
Precautions
Leukeran, a derivative of the nitrogen mustard chemical group is a veterinary medication used in treating leukemia as well as Hodgkin’s disease in dogs and cats. Recognized as the alkylating agent, the medication is also effective in the management of the cancer affecting lymphatic system and tumors. The drug is also used in treating certain other immune-mediated conditions in animals. Chlorambucil, the active ingredient present in the medication is an antineoplastic and immunosuppressant, which acts by connecting DNA strands to modify protein formation. The medication also augments the production of lymphocytes, thus proving effective in the management of diseases that affects the immune system of animals, especially in cats. Leukeran is available only by prescription and comes in 2mg sugar coated tablets.
Side Effects
Chlorambucil works similar to chemotherapy that is sure to have issues with side effects. Bone marrow suppression is one of the most common of the adverse reactions that animals encounter. This can lead to anemia, or/and a decrease in the WBC count, though the animals will regain health when the medication is discontinued. Also, the hairy breeds in cats and dogs can experience hair loss.
Dosage Information
The conditions for which the animals are being treated differ, so is the dosage, frequency and duration of medication. However, dogs are usually prescribed a dosage of 0.1mg/lbs to be provided orally for about two weeks. In cats, it is 0.05-0.1mg/lbs daily. In either case, continue the medication till the prescribed duration, even if the animal is registering steady improvement.
Brand Names
Chlorambucil (Leukeran)