Benazepril hydrochloride should be used cautiously in patients with hyponatremia, coronary or cerebrovascular insufficiency, pre existing hematologic disease, or systemic lupus erythematosus. Pregnant patients should only take benazepril if the benefits outweigh the risks to the fetus. Patients suffering from a severe congestive heart failure should be closely monitored upon starting a benazepril treatment.
Taking with diuretics or other vasodilators can cause hypotension. NSAIDs might reduce the antihypertensive effects. Hyperkalemia might be a result of taking benazepril and potassium sparing diuretics at the same time.