The drug should not be used in animals with hypersensitivity, allergy to antihistamine, glaucoma, high blood pressure, lung disease, heart disease, and prostate enlargement. The drug is not recommended for use in pregnant or nursing animals. Extreme caution is required when used in pets with urinary obstruction and intestinal obstruction. Possible drug interactions have been observed. The medication should not be used with drugs like barbiturates, tranquilizers, and Epinephrine. Precaution is required when given with CNS depressant drugs like Acepromazine, monoamine oxidase inhibitors (MAOIs) like Selegilene, and preventic collars and drugs used for wheezing such as Theophylline, Epinephrine, or Ephedrine. Store the drug at room temperature, away from excess heat and moisture.