Hydroxyzine should not be used in animals with hypersensitivity, allergy to antihistamine, glaucoma, high blood pressure, lung disease, heart disease, and prostate enlargement. Hydroxyzine is not recommended for use in pregnant or nursing animals. Extreme caution is required when using Hydroxyzine in pets with urinary obstruction and intestinal obstruction. Hydroxyzine should not be used with drugs like barbiturates, tranquilizers, and Epinephrine as negative interactions have been observed. Precaution is required when given with CNS depressant drugs like Acepromazine, monoamine oxidase inhibitors (MAOIs) like Selegilene, and preventic collars and drugs used for wheezing such as Theophylline, Epinephrine, or Ephedrine. Store Hydroxyzine at room temperature, away from excess heat and moisture.