Advantage Multi for Cats are found in topical prescription medications with effective components for flea control and heartworm prevention, and come with endectocides, endoparasiticides and ectoparasiticides properties. Medications with Advantage Multi for Cats commonly are used for the prevention of heartworm disease caused by L3 and L4 larvae of Dirofilaria immitis. These medications are chiefly indicated for the treatment of flea infestations (Ctenocephalides felis) and ear mite infestations (Otodectes cynotis). Medications with Advantage Multi for Cats are effective as a treatment strategy for flea allergy dermatitis (FAD) and also for the elimination of certain intestinal parasites in cats. Imidacloprid exhibits high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the CNS of the flea, resulting in the paralysis and death of the insect. Moxidectin is efficient to fight internal and external parasites including larval stages (L3, L4) of Dirofilaria immitis and gastrointestinal nematodes. Moxidectin interacts with GABA and glutamate-gated chloride channels, resulting in the opening of the chloride channels on the postsynaptic junction. This action triggers the inflow of chloride ions and creates a permanent resting state, resulting in the paralysis and eventually the death of the parasite.