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2x PetCareRx Points
Requires Prescription
At a Glance
Comfortis is safe for use in dogs and cats
Prevents flea infestations for a full 30 days
Kills fleas within 30 minutes


Comfortis is the first beef-flavored chewable that both kills fleas and prevents infestations in your dog or cat for a full 30 days. Comfortis is safe for puppies and kittens as young as 14 weeks. [+]

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This product requires a prescription.
  • Other Customers Also Bought for their Pet

    • Kills fleas and ticks within 12 hours
    • Kills flea eggs, pupae, larvae, and adults for 30 days
    • Kills and protects against mosquitoes, which are the primary cause of heartworm
    • Protect your dog from a variety of disease carrying ticks
    • Kills fleas, and controls American Dog Tick infestations
    • Once a month spot on to prevent internal and external parasites including heartworm
    • Treats and controls ear mites and sarcoptic mange
    • Water-based, pH balanced, and non-irritating
    • Guaranteed not to rinse out flea and tick medicine
    • Lathers up quick and rinses out easily
    • Fresh, clean fragrance

Customer Reviews

Rated 4.8 out of 5 by 228 reviewers.
Rated 4 out of 5 by Need to add tick protection Seems to work regarding fleas, but our dog got a tick within a week of first tablet. I know Comfortis only advertises flea protection, but if possible, adding tick protection would be a great help. And, this stuff is expensive requiring a vet prescription. May have to find alternative. October 8, 2015
Rated 5 out of 5 by good stuff This has been the worst year for the fight the fleas. I used to use Advantix. that didn't even work. this is the best stuff out there. September 12, 2015
Rated 5 out of 5 by This Product Works! Our two Dogs and one Cat had been on Advantage for years. A couple of years ago it basically quit working! We had a Flea Investation in our Florida and Georgia home and our pets were going crazy. Our Vet recommended Comfortis and we bombed both our homes for a few hours each. Within a day everything was back to scratching, no fleas. Thanks, Doug Mitchell May 26, 2015
Rated 5 out of 5 by Effective and easy to use! Only one that has been consistently effective. We have used several other brands, most were not effective and messy to use as well. April 29, 2015
Rated 5 out of 5 by Very good price! This was the first time I ordered from Pet Care RX and I am very pleased with the products and the service. April 23, 2015
Rated 5 out of 5 by Best Flea Medicine Ever! Our dog is allergic to flea bites and we have tried all of the top brands and even prescription medicine from vet. They either don't work as advertised or they make her sick. Finally, Comfortis became available and my vet. was as interested as we were to see if this would be the "flea med." that would really work and not make our dog sick. Well, IT DOES WORK AND IT DOESN'T MAKE OUR DOG SICK!!! Ask your vet. about Comfortis. You can order it through this site and they will contact your vet. direct. It is easy to do. We give the tablet to our dog with her dinner and she is fine with it. We are so happy that she no longer has to suffer. Also, because Comfortis repels fleas she doesn't bring any in to the house or car! Big Bonus for all of us! April 6, 2015
Rated 5 out of 5 by My dogs love it My two dogs use this monthly. They can not take whole tab at one time so I have to cut in half and give each one two halves separately. They used to just take the tabs au natural but now they both expect their meds in Pill Pockets so that's how they get their Comfortis... It's less expensive buying from Petcarerx then getting them from my own vet. March 23, 2015
Rated 5 out of 5 by Great solution for cat fleas! Our poor cat was acting unusual which I finally realized it was from our dog having fleas. Now the cat had them! This product works within 30 minutes and REALLY works great! FYI: Make sure your cat eats before/after giving the medication. February 21, 2015
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Customer Q&A

Lilly Flea & Tick Comfortis Flea Preventative Comfortis is the first beef-flavored chewable that both kills fleas and prevents infestations in your dog or cat for a full 30 days. Comfortis is safe for puppies and kittens as young as 14 weeks. prescription 107.99 Condition: new In stock! Order now!
Comfortis Flea Preventative 5 out of 5 0 based on 228 ratings.