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Product Reviews

Trifexis is a powerful and effective means of preventing heartworm disease, as well as protect against fleas and a number of other worms and parasites. More »

$124.99 - $139.99
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Rated 4.3 out of 5 by 90 reviewers.
Rated 3 out of 5 by It works One stop shopping for dogs & their owners. One pill for multiple uses than giving dogs three different pills. October 19, 2013
Rated 4 out of 5 by All in one heart guard and pest control medicine Great product for the one and done folks. Pill itself is a little large and must be broken up (and mixed with treats) for our pet to take. October 16, 2013
Rated 5 out of 5 by Great Product I will definitely continue to use Trifexis for my two dogs. I have been using it for a couple of years now and I have had zero problems with fleas and/or ticks. Usually, I smash the pill up inside a plastic bag with a rolling pin and then empty the pill into some wet dog food. My dogs eat it up like they normally would eat a treat like that. My dogs are very healthy and happy! It is a little pricey, but I think it is worth it!! It definitely beats having to worry about fleas on your dog, on you, and all over your house! October 11, 2013
Rated 5 out of 5 by I think is too expensive. Most folks can't afford this for their pets & that's too bad because Our pet has not had worms,fleas,or ticks & that's grea It works great.Max has not tested positive for worms while on this medication. He has not had a flea or a tick on him While he has been on it either. October 8, 2013
Rated 1 out of 5 by Not worth the money I have a 13Lb 3yr old pug. She is normally happy and energetic. I normally give her the plus version of a leading brand of topical flea treatment that protects against everything but heartworms. I thought to switch to this product so I would not have to administer an additional heartworm pill and I thought I was doing her a favor by not applying chemicals to her skin. I split the pill into quarters and mixed it with chicken. I could tell by the look in her face that she disliked it very much. She has been much less energetic since I gave her the pill five days ago. She is itchy and seems to pay more attention than ever to her genital area. So, now I don't have to give her a separate heart pill, but I have to worry about ticks, flea pupae, itching, lethargy, "licking of the genitals" and the guilt of giving her a large and distasteful pill. For the money, I expect better. I figure I can go back to the topical treatment and at least she is protected against ALL stages of fleas AND ticks, plus she does not mind the taste of the heart pill. September 30, 2013
Rated 5 out of 5 by Great Product but... I LOVED this product only reason I stopped using it was cause it was NOT tested on breeding males which my dog is. But for the time I was using this product it did wonders for getting rid of the fleas kept the ticks down (we hike a lot). September 16, 2013
Rated 5 out of 5 by Great product, totally works, and petcarerx offers it at a great price! We've been using this product as well as PetCarerx for close to four years now and are extremely happy with the level of service and value. September 5, 2013
Rated 4 out of 5 by GOOD ALL IN ONE This is a good all in one flee plus heart guard. It did well for one of my dogs, but no so much the other one. Not sure why. My dog does not like the taste, so I have to put in food before he will take it. August 15, 2013
Rated 5 out of 5 by Works for both of my dogs Both of my dogs have been using Trifexis since we got them and we have never had a single flea. This is even more amazing because we live in the country and have all kinds of wildlife going through our yard. August 12, 2013
Rated 4 out of 5 by Trifexis has worked for us The only problem we have had with this product is that my one picky dog will not eat it willingly. But we coat it in peanut butter and then all is well. My dogs have both been taking Trifexis for many months and it appears to be effective. August 7, 2013
Rated 5 out of 5 by Trifixes really works. I was giving my 4 month old Multees the topic medication that you put in the back of the neck. I thought she was safe from tick and fleas. Boy was I wrong. One day after shower her, I saw lot of fleas on her and panicked as Im sure most of you will. Trifexes was recommended through a friend of mine who had a dog and recommended me to use it. After much research, I asked my vet if its ok to use it. Make the long story short, after first application it worked wonders. No more fleas, ticks or nothing. My dog is healthy and I believe this product really works. One pill a month orally and thats it. You dont have to worry about any ticks or nothing. Man Im so glad I found Trifexes Its a little expensive, but hey I dont care, as long as my puppy is healthy, thats all i care about. August 7, 2013
Rated 5 out of 5 by Great preventative med Such an easy product to use. Not only to prevent worms but bonus flea protection. August 6, 2013
Rated 5 out of 5 by This product works great for sensitive dogs...I have a pug.. This product works great for sensitive dogs...I have 2 pugs and have not had any problems... July 23, 2013
Rated 5 out of 5 by Great Product I love this product for my puppy. I hated to put something on her skin. I always felt that was harsh. I have never seen anything on her. It even killed the one tick that was one her. July 22, 2013
Rated 5 out of 5 by 3 birds, 1 stone I like that I don't have to worry about separate meds for heartworm and fleas. It's expensive, but evens out when you combine other med costs. My dog's only gotten sick from it once, and I think it was because I gave it to her too late after she finished eating for the night. July 22, 2013
Rated 4 out of 5 by Good for small dogs My dog is under 5 pounds. With some of the flea medications, you need to be careful because they are "for under 20 pounds" and even so, some are too much for such a little dog. This medication is fine for her. It does make her a little lethargic but only for about 1 day. As far as I know, it works. I haven't had any flea issues. I think it's expensive but they all are these days. July 20, 2013
Rated 5 out of 5 by Works well I wish it were more palatable to our dog. She hates the taste. WILL NOT eat it, not even swallow it in small pieces. I have to pulverize it. She is usually a pretty good pill taker. (has to take 4 pills per day' just toss them onto the back of her tongue, and rub her throat and offer her a treat. However, nothing works with the Trifexis! PLEASE tell the company to make it more "dose easy"! July 19, 2013
Rated 4 out of 5 by Trifexis works well from Florida it is a definite asset other than the cost & the dogs HATE it , they take heartguard like a cookie, for the cost you have to become quite creative. not only my dogs my sister in law turned me on to trifexis & has the same trouble To get them to eat it! July 16, 2013
Rated 5 out of 5 by Highly recommended. If it was in a chewy tab, my dogs would like it better, but I love the ease and the effectiveness of this product, I JUST CRUSH THE TABLETS IN THE PACKAGE, OPEN IT UP POUR OVER DRY FOOD AND THEN ADD A LITTLE WET FOOD TO MIX IT IN AND THEY EAT IT UP. I hated the flea products that you administer to there skin as I have a black lab with long thick hair and a vizla and they love water and never felt the products were as effective. July 16, 2013
Rated 5 out of 5 by A good product! I live in a rural area and my dogs were constantly infested with fleas, despite using various flea products. Since I started Trifexus over a year ago, I have not seen 1 flea on either of them! July 12, 2013
Rated 5 out of 5 by Love it! I live out in the country, and both my dogs were fighting fleas and ticks even with 3-4 week spot treatments and they both had hookworm. The first time I used Trifexis, they were both nauseated with the first dose and didn't digest the entire tablet, but I still noticed a reduction in fleas and stomach problems. They weren't as nauseated with the second dose. We are at two full months now, and I haven't seen a flea or tick in at least 4-6 weeks, and it doesn't even say anything about tick preventative. They are also both free of hookworms, and their skin is getting clearer from where they had been scratching. I love that this gives heartworm, flea, and intestinal worm treatments all in one product, and the cost is great compared to buying two or three different products. My vet recommended this to me because he uses it for his dog, and I would definitely recommend it to other people. June 29, 2013
Rated 4 out of 5 by I have a minature schnauzer 16 lbs, have been giving it to her for about 2 years. The price continues to go up each time I buy a 6 month supply. Besides the price going up each time I buy, it makes her very itchy, so then I have to give her another pill to try to combat the itching (Temeril P), which makes it more expensive April 23, 2013
Rated 4 out of 5 by Not one flea but.... We have a mini dachshund. I added up the cost and this product was cheaper than having to buy all monthly products (heartgaurd, wormer, etc..) by around $5-$10. I don't have any problem with her taking it. It is a hard pill and with other products I have been known to roll cheese around it. However, the only issue thus far has been the itching. I thought at first she had fleas, then just dry skin but after reading up this product has a side affect of itching. She also got tapeworms so I'm assuming it doesn't protect against them. She mainly an indoor dog but on pretty days she spends a good dosage of outside time. March 26, 2013
Rated 3 out of 5 by Expensive but Effective This product is Effective. I have not seen a flea on my dog and we live in Florida. We will see when summer hits if it is truly repellent of fleas. I gave low ease of use because it is not chewable. I have to fight with her every month to take it. She smells it and cowers down. I cannot put it in cheese or meat because she won't eat it. I did however discover smothering it with peanut butter and then cheese works the best. It still requires a fight. Also, this is a very expensive pill and you cannot afford any monthly mistakes. I wish it was a little cheaper. It is definitely making me look for an alternative. March 16, 2013
Rated 4 out of 5 by Very Effective My Dachshund gets this produce once a month and it is VERY effective. Be careful to order the correct dosage because it is dangerous if you give a more powerful strength than needed. I recommend this product over Comfortis. Mo weighs 13lbs so she gets the one for dogs 10.1-20 pounds. Be sure to give your dog food when you give this product because it could possibly upset your pet's stomach. Mo eats it no problem, I don't even have to disguise it in a dog treat or break it up. March 12, 2013
Rated 4 out of 5 by Great Heart Worm Medicine/Flea Protection Hello Everyone, I have a 10 year old Golden Retriever now and my Vet recommended I put her on Trifexis and Front Line plus simply because I live in a wooden area that and she allergic to flea saliva bites. I been using Trifexis for nearly two years now and its a Great Preventive against worms and that fleas may carry. The reason I have it a Two bar on Ease of Use is because she will not chew it I have to kinda break it down is sections for her just for her to eat it. Plus You have to give your pet a meal before giving this medicine to them or other wise it upsets the stomach and will cause them to throw up. Other then that its a great product! Only Reason it got a four star from me is because its not a easy chew tablets for my dog. But, if anyone was to ask me on what type of flea/heart medication to put there pet on I would tell them to do Trifexis and Front Line plus because you will get double the protection and the Front Line Plus will protect your pet from Ticks!!! February 28, 2013
Rated 5 out of 5 by Five months--so far, so good! My 6 year-old male miniature poodle came home after several warm winter months in Florida with the first fleas of his life last year. We worked for months using several alternating brands of skin applications (one of which we had already been regularly using) trying to no avail to end the infestation. We sprayed, we had the house professionally fumigated and still had fleas. Finally, Trifexis quickly solved the problem. He always loved his heartworm pills, but these are so large he needs two tries to get them down. So far, no adverse reactions, no heartworms and no fleas! February 25, 2013
Rated 4 out of 5 by Effective - IF YOU CAN GET IT IN YOUR DOG! "Ease of use" hardly applies. My dogs run away when they get one whiff of this so-called "chewable" tablet. Even wrapped in a piece of chicken it takes numerous tries. As effective as this product is, I sure would like to see it made at least palatable . February 22, 2013
Rated 4 out of 5 by This product combines Heartworm & Flea meds. I'm really grateful for Trifexis. I was giving my Chow 1 pill for Heartworms & 1 for Fleas, now I only give her 1 pill a month. It has cut my cost by about 25-30% every 6 months. The description reads that it's beef flavored and to give w/food but, she eats around it and I don't blame her. When I take it out of the package, it has a strong smell of dirt so, I let it sit out for a couple hours hoping it will help with the smell but it doesn't. I still let it sit out, but now I cut it into four pieces and give it to her in cheese. February 16, 2013
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